abstract：:Glioblastomas are aggressive brain tumors that frequently recur in the subventricular zone (SVZ) despite maximal treatment. The purpose of this study was to evaluate imaging patterns of subventricular progression and impact of recurrent subventricular tumor involvement and radiation dose to patient outcome. Retrospect...

journal_title：Journal of neuro-oncology

authors： Weinberg BD,Boreta L,Braunstein S,Cha S

更新日期：2018-07-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are important modulators of various cellular and molecular events, including cancer-associated pathways. The Anti-differentiation ncRNA (ANCR) is a key regulator of keratinocyte differentiation, where its expression is necessary to maintain epidermal progenitor's cells. Herein, we invest...

journal_title：Journal of neuro-oncology

authors： Malakootian M,Mirzadeh Azad F,Fouani Y,Taheri Bajgan E,Saberi H,Mowla SJ

更新日期：2018-06-01 00:00:00

abstract：:Immune checkpoint inhibitors targeting programmed cell death 1 (PD-1) or its ligand (PD-L1) have been shown to be effective in treating patients with a variety of cancers. Biomarker studies have found positive associations between clinical response rates and PD-L1 expression on tumor cells, as well as the presence of ...

journal_title：Journal of neuro-oncology

authors： Wang S,Liechty B,Patel S,Weber JS,Hollmann TJ,Snuderl M,Karajannis MA

更新日期：2018-05-01 00:00:00

abstract：:The objective of this study was to investigate racial/ethnic differences in survival for pediatric high-grade glioma (HGG) and medulloblastoma in the state of California. We obtained data from the California Cancer Registry on 552 high-grade glioma patients (110 brainstem, 442 non-brainstem) and 648 medulloblastoma pa...

journal_title：Journal of neuro-oncology

authors： Cooney T,Fisher PG,Tao L,Clarke CA,Partap S

更新日期：2018-05-01 00:00:00

abstract：:Glioblastoma (GBM) is the most malignant primary brain tumor and contains tumorigenic cancer stem cells (CSCs), which support the progression of tumor growth. The selection of CSCs and facilitation of the brain tumor niches may assist the development of novel therapeutics for GBM. Herein, hydrogel materials composed o...

journal_title：Journal of neuro-oncology

authors： Liu YC,Lee IC,Chen PY

更新日期：2018-05-01 00:00:00

abstract：:Glioblastomas are malignant brain tumors with poor prognosis. Lately, data from clinical studies assessing the role of co-medications in different cancer types suggested reduced mortality and potential anti-tumor activity for statins, angiotensin-I converting enzyme inhibitors (ACEI) and angiotensin II receptor blocke...

journal_title：Journal of neuro-oncology

authors： Happold C,Gorlia T,Nabors LB,Erridge SC,Reardon DA,Hicking C,Picard M,Stupp R,Weller M,EORTC Brain Tumor Group and on behalf of the CENTRIC and CORE Clinical Trial Groups.

更新日期：2018-05-01 00:00:00

abstract：:Assessing central nervous system (CNS) involvement in patients with lymphoma or carcinoma is important in determining therapy and prognosis. Progranulin (PGRN) is a secreted glycosylated protein with roles in cancer growth and survival; it is highly expressed in aggressive cancer cell lines and specimens from many can...

journal_title：Journal of neuro-oncology

authors： Kimura A,Takemura M,Serrero G,Yoshikura N,Hayashi Y,Saito K,Inuzuka T

更新日期：2018-05-01 00:00:00

abstract：:Malignant glioma (MG), the most common primary brain tumor in adults, is extremely aggressive and uniformly fatal. Several treatment strategies have shown significant preclinical promise in murine models of glioma; however, none have produced meaningful clinical responses in human patients. We hypothesize that introdu...

journal_title：Journal of neuro-oncology

authors： Filley A,Henriquez M,Bhowmik T,Tewari BN,Rao X,Wan J,Miller MA,Liu Y,Bentley RT,Dey M

更新日期：2018-05-01 00:00:00

abstract：:Ependymomas (EPN) show site specific genetic alterations and a recent DNA methylation profiling study identified nine molecular subgroups. C11orf95-RELA and YAP1 fusions characterise the RELA and YAP1 molecular subgroups, respectively, of supratentorial (ST)-EPNs. Current guidelines recommend molecular subgrouping ove...

journal_title：Journal of neuro-oncology

authors： Malgulwar PB,Nambirajan A,Pathak P,Faruq M,Rajeshwari M,Singh M,Suri V,Sarkar C,Sharma MC

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We aimed to compare three-dimensional conformal radiotherapy (3D-CRT) with intensity-modulated radiotherapy (IMRT) for the treatment of glioblastoma. MATERIALS AND METHODS:Retrospective study of 220 patients with glioblastoma, treated with 3D-CRT or IMRT, with or without surgery. Dosimetric para...

journal_title：Journal of neuro-oncology

authors： Thibouw D,Truc G,Bertaut A,Chevalier C,Aubignac L,Mirjolet C

更新日期：2018-04-01 00:00:00

abstract：:Previous study revealed that higher expression of transforming growth factor beta induced (TGFBI) is correlated to poorer cancer-specific survival and higher proportion of tumor necrosis and Fuhrman grades III and IV in clear cell renal cell carcinomas. However, the relationships between TGFBI expression and malignant...

journal_title：Journal of neuro-oncology

authors： Pan YB,Zhang CH,Wang SQ,Ai PH,Chen K,Zhu L,Sun ZL,Feng DF

更新日期：2018-04-01 00:00:00

abstract：:The diagnosis of leptomeningeal metastases (LM) of solid tumors is complicated due to low sensitivities of both magnetic resonance imaging (MRI) and cytology. MRI has a sensitivity of 76% for the diagnosis of LM and cerebrospinal fluid (CSF) cytology has a sensitivity of 44-67% at first lumbar puncture which increases...

journal_title：Journal of neuro-oncology

authors： van Bussel MTJ,Pluim D,Bol M,Beijnen JH,Schellens JHM,Brandsma D

更新日期：2018-03-01 00:00:00

abstract：:Recurrent pediatric high-grade glioma is a leading cause of cancer-related death in children. We report results of a systematic review and meta-analysis investigating survival outcome in pediatric patients with recurrent high-grade glioma over the last 20 years. MEDLINE/PubMed, EMBASE, Web of Science and Cochrane Revi...

journal_title：Journal of neuro-oncology

authors： Kline C,Felton E,Allen IE,Tahir P,Mueller S

更新日期：2018-03-01 00:00:00

abstract：:In sporadic schwannomas, inactivation of both copies of the NF2 tumor suppressor gene on 22q is common. Constitutional mutations of SMARCB1 are responsible of schwannomatosis, an inherited tumor predisposition syndrome, characterized by the development of multiple schwannomas. We analysed the frequency of copy number ...

journal_title：Journal of neuro-oncology

authors： Paganini I,Capone GL,Vitte J,Sestini R,Putignano AL,Giovannini M,Papi L

更新日期：2018-03-01 00:00:00

abstract：:The actual role of 18F-FDG PET/CT in evaluating primary brain lymphoma is still an open issue. Brain lymphoma usually show elevated 18F-FDG uptake, often higher than other brain tumors or inflammatory processes, but the metabolic behavior of this lymphoma is not still understood. Our aim was to investigate the particu...

journal_title：Journal of neuro-oncology

authors： Albano D,Bosio G,Bertoli M,Giubbini R,Bertagna F

更新日期：2018-02-01 00:00:00

abstract：:Hospital readmissions are a major contributor to increased health care costs and are associated with worse patient outcomes after neurosurgery. We used the newly released Nationwide Readmissions Database (NRD) to describe the association between patient, hospital and payer factors with 30- and 90-day readmission follo...

journal_title：Journal of neuro-oncology

authors： Donoho DA,Wen T,Babadjouni RM,Schwartzman W,Buchanan IA,Cen SY,Zada G,Mack WJ,Attenello FJ

更新日期：2018-01-01 00:00:00

abstract：:The members of the PERNO Study Group were not individually captured in the metadata of the original publication. They are included in the metadata of this publication. ...

journal_title：Journal of neuro-oncology

authors： Franceschi E,Depenni R,Paccapelo A,Ermani M,Faedi M,Sturiale C,Michiara M,Servadei F,Pavesi G,Urbini B,Pisanello A,Crisi G,Cavallo MA,Dazzi C,Biasini C,Bertolini F,Mucciarini C,Pasini G,Baruzzi A,Brandes AA,PERNO

更新日期：2018-01-01 00:00:00

abstract：:To date, no histopathological vascular investigation focusing on peritumoral brain zone (PBZ) has been reported for glioblastoma. We analyzed 10 newly diagnosed cases of glioblastomas. For these PBZs, histopathological investigation was performed by hematoxylin-eosin (H&E) staining and immunohistochemistry was analyze...

journal_title：Journal of neuro-oncology

authors： Tamura R,Ohara K,Sasaki H,Morimoto Y,Yoshida K,Toda M

更新日期：2018-01-01 00:00:00

abstract：:Treatment of infant hypothalamic chiasmatic glioma (iCHG) is challenging, about 30% of the children progress during chemotherapy. Despite subsequent treatments the 5 year overall-survival rate is only 70%. This study investigates treatment strategies currently applied for progressive iCHG. A web-based questionnaire wa...

journal_title：Journal of neuro-oncology

authors： Azizi AA,Schouten-van Meeteren AYN

更新日期：2018-01-01 00:00:00

abstract：:We aimed to assess the efficacy of stereotactic irradiation for patients with recurrent high-grade glioma (HGG) and identify predictive factors of progression-free survival (PFS) and overall survival (OS) following reirradiation. We identified 32 patients with recurrent brain HGG who had been treated with either singl...

journal_title：Journal of neuro-oncology

authors： Attal J,Chaltiel L,Lubrano V,Sol JC,Lanaspeze C,Vieillevigne L,Latorzeff I,Cohen-Jonathan Moyal E

更新日期：2018-01-01 00:00:00

abstract：:Intracranial melanotic schwannomas (IMSch) are extremely rare nerve sheath tumors with features of Schwann cells that produce melanin. After a thorough review of the available literature since 1967, we report not only the 20th case of IMSch but a comprehensive modern-era analysis of radiographic and histological key-p...

journal_title：Journal of neuro-oncology

authors： Mahato D,Vivas-Buitrago T,Gassie K,Jentoft M,Tavanaiepour D,Quiñones-Hinojosa A

更新日期：2018-01-01 00:00:00

abstract：:We characterized health-related quality of life (HRQoL), cognitive, and functional status in newly diagnosed glioblastoma (GBM) patients receiving Tumor treating fields (TTFields) with temozolomide (TMZ) versus TMZ alone in a planned interim analysis of a randomized phase III trial [NCT00916409], which showed signific...

journal_title：Journal of neuro-oncology

authors： Zhu JJ,Demireva P,Kanner AA,Pannullo S,Mehdorn M,Avgeropoulos N,Salmaggi A,Silvani A,Goldlust S,David C,Benouaich-Amiel A,Zvi Ram on behalf of the EF-14 Trial Investigators.

更新日期：2017-12-01 00:00:00

abstract：:The relation between hospital volume and outcomes for patients with glioblastoma is unknown. We undertook this study to determine the effect of hospital volume on treatment received and its effect on survival in patients with glioblastoma. We included patients from the National Cancer Database diagnosed with a gliobla...

journal_title：Journal of neuro-oncology

authors： Koshy M,Sher DJ,Spiotto M,Husain Z,Engelhard H,Slavin K,Nicholas MK,Weichselbaum RR,Rusthoven C

更新日期：2017-12-01 00:00:00

abstract：:Computational modeling shows that intra-arterial delivery is most efficient when the delivered drugs rapidly and avidly bind to the target site. The cell-penetrating peptide trans-activator of transcription (TAT) is a candidate carrier molecule that could mediate such specificity for brain tumor chemotherapeutics. To ...

journal_title：Journal of neuro-oncology

authors： Joshi S,Cooke JRN,Ellis JA,Emala CW,Bruce JN

更新日期：2017-12-01 00:00:00

abstract：:Glioblastoma stands out as the most frequent central nervous system neoplasia, presenting a poor prognosis. The aim of this study was to verify the frequency and clinical significance of the aneuploidy of chromosomes 7 and 10, EGFR amplification, PTEN and TP53 deletions and 1p/19q deficiency in adult patients diagnose...

journal_title：Journal of neuro-oncology

authors： Koshiyama DB,Trevisan P,Graziadio C,Rosa RFM,Cunegatto B,Scholl J,Provenzi VO,de Sá AP,Soares FP,Velho MC,de A P Filho N,Oliveira CA,Zen PRG

更新日期：2017-12-01 00:00:00

abstract：:The embolization of cancer cells to cerebral vessels occurs early in the multi-step metastatic process. We aimed to determine whether the presence of leukoaraiosis (LA) before treatment would predict the development of brain metastases (BM) in patients with lung cancer. Between January 2014 and June 2015, 1007 patient...

journal_title：Journal of neuro-oncology

authors： Hayashi N,Mitsuya K,Nakasu Y,Naito T,Ohka F,Takahashi T

更新日期：2017-11-01 00:00:00

abstract：:Ependymoma is the third most common brain tumor in children, but there is a paucity of large studies with more than 10 years of follow-up examining the long-term survival and recurrence patterns of this disease. We conducted a retrospective chart review of 103 pediatric patients with WHO Grades II/III intracranial epe...

journal_title：Journal of neuro-oncology

authors： Marinoff AE,Ma C,Guo D,Snuderl M,Wright KD,Manley PE,Al-Sayegh H,Sinai CE,Ullrich NJ,Marcus K,Haas-Kogan D,Goumnerova L,London WB,Kieran MW,Chi SN,Fangusaro J,Bandopadhayay P

更新日期：2017-10-01 00:00:00

abstract：:While stereotactic radiosurgery (SRS) has been shown effective in the management of brain metastases, small brain metastases (≤10 mm) can pose unique challenges. Our aim was to investigate the efficacy of SRS in the treatment of small brain metastases, as well as elucidate clinically relevant factors impacting local f...

journal_title：Journal of neuro-oncology

authors： Trifiletti DM,Hill C,Cohen-Inbar O,Xu Z,Sheehan JP

更新日期：2017-09-01 00:00:00

abstract：:Primary brain tumor patients experience high levels of distress. The purpose of this cross-sectional, retrospective study is to evaluate the level and different sources of psychosocial distress and how these pertain to health-related quality of life (HRQoL). The Primary and Recurrent Glioma registry at Duke's The Pres...

journal_title：Journal of neuro-oncology

authors： Randazzo DM,McSherry F,Herndon JE 2nd,Affronti ML,Lipp ES,Flahiff C,Miller E,Woodring S,Freeman M,Healy P,Minchew J,Boulton S,Desjardins A,Vlahovic G,Friedman HS,Keir S,Peters KB

更新日期：2017-09-01 00:00:00

abstract：:Pilocytic astrocytomas are rare intracranial gliomas that are typically treated with surgical extirpation. Our aim was to report the radiologic and clinical outcomes of patients treated with stereotactic radiosurgery (SRS) for pilocytic astrocytoma in the primary and salvage setting. Patients with pilocytic astrocytom...

journal_title：Journal of neuro-oncology

authors： Trifiletti DM,Peach MS,Xu Z,Kersh R,Showalter TN,Sheehan JP

更新日期：2017-09-01 00:00:00

abstract：:The EORTC trial which solidified the role of external beam radiotherapy (EBRT) plus temozolomide (TMZ) in the management of GBM excluded patients over age 70. Randomized studies of elderly patients showed that hypofractionated EBRT (HFRT) alone or TMZ alone was at least equivalent to conventionally fractionated EBRT (...

journal_title：Journal of neuro-oncology

authors： Glaser SM,Dohopolski MJ,Balasubramani GK,Flickinger JC,Beriwal S

更新日期：2017-08-01 00:00:00

abstract：:The value of perfusion and diffusion-weighted MRI in differentiating histological subtypes according to the 2007 WHO glioma classification scheme (i.e. astrocytoma vs. oligodendroglioma) and genetic subtypes according to the 2016 WHO reclassification (e.g. 1p/19q co-deletion and IDH1 mutation status) in WHO grade II a...

journal_title：Journal of neuro-oncology

authors： Leu K,Ott GA,Lai A,Nghiemphu PL,Pope WB,Yong WH,Liau LM,Cloughesy TF,Ellingson BM

更新日期：2017-08-01 00:00:00

abstract：:Immune checkpoint inhibitors have demonstrated remarkable benefits in cancer patients. However, concern regarding toxicity in the setting of stereotactic radiosurgery (SRS) is often raised. In this study, we characterize radiation necrosis (RN) following immunotherapy and SRS. Melanoma patients treated with SRS and an...

journal_title：Journal of neuro-oncology

authors： Fang P,Jiang W,Allen P,Glitza I,Guha N,Hwu P,Ghia A,Phan J,Mahajan A,Tawbi H,Li J

更新日期：2017-07-01 00:00:00

abstract：:Accumulating evidence has supported the role of microRNAs in the initiation and development of malignant tumors. MicroRNA-211 (miR-211), which was reported to involve in diverse physiological activities in several cancers, was investigated for its expression in human glioma and adjacent normal brain tissues, as well a...

journal_title：Journal of neuro-oncology

authors： Zhang J,Lv J,Zhang F,Che H,Liao Q,Huang W,Li S,Li Y

更新日期：2017-07-01 00:00:00

abstract：:Glioma is the most common primary brain tumor in adults. Six3 is a human homologue of the highly conserved sine oculis gene family and essential transcription regulatory factor in process of eye and fetal forebrain development. However, little is known about the role of Six3 in human tumorigenesis. The aim of this stu...

journal_title：Journal of neuro-oncology

authors： Zhang B,Shen C,Ge F,Ma T,Zhang Z

更新日期：2017-07-01 00:00:00

abstract：:Anti-PD-1/PD-L1 therapies have demonstrated activity in patients with advanced stage non-small cell lung cancer (NSCLC). However, little is known about the safety and feasibility of patients receiving anti-PD-1/PD-L1 therapy and stereotactic radiation for the treatment of brain metastases. Data were analyzed retrospec...

journal_title：Journal of neuro-oncology

authors： Ahmed KA,Kim S,Arrington J,Naghavi AO,Dilling TJ,Creelan BC,Antonia SJ,Caudell JJ,Harrison LB,Sahebjam S,Gray JE,Etame AB,Johnstone PA,Yu M,Perez BA

更新日期：2017-06-01 00:00:00

abstract：:During glioma resection, 5-aminolevulinic acid (5-ALA) and fluorescein sodium (Fl-Na) are used for photodynamic tumor visualization. The objective of this study was to evaluate the pathological findings of the boundary zone between the tumor and adjacent normal brain in glioblastoma patients undergoing simultaneous do...

journal_title：Journal of neuro-oncology

authors： Yano H,Nakayama N,Ohe N,Miwa K,Shinoda J,Iwama T

更新日期：2017-06-01 00:00:00

abstract：:Primary malignant brain and other central nervous system tumors (BT) are a rare cancer that causes morbidity and mortality disproportionate to their incidence. This study presents the most up-to-date mortality data for malignant BT in the United States (US) by histology groupings, age, race, and sex. Mortality rates f...

journal_title：Journal of neuro-oncology

authors： Gittleman H,Kromer C,Ostrom QT,Blanda R,Russell J,Kruchko C,Barnholtz-Sloan JS

更新日期：2017-06-01 00:00:00

abstract：:To investigate late toxicity among patients with newly-diagnosed brain metastases undergoing stereotactic radiosurgery (SRS) with concurrent systemic therapies with or without whole-brain radiation therapy (WBRT). Patients with newly-diagnosed brain metastasis who underwent SRS at a single tertiary-care institution fr...

journal_title：Journal of neuro-oncology

authors： Kim JM,Miller JA,Kotecha R,Xiao R,Juloori A,Ward MC,Ahluwalia MS,Mohammadi AM,Peereboom DM,Murphy ES,Suh JH,Barnett GH,Vogelbaum MA,Angelov L,Stevens GH,Chao ST

更新日期：2017-06-01 00:00:00

abstract：:Data concerning treatment of secondary glioblastoma evolving from previously treated WHO II or III grade tumors are very scarce. The aim of this study was to evaluate the impact of surgical resection and adjuvant treatment on survival in patients with secondary glioblastoma. Thirty-nine patients with secondary gliobla...

journal_title：Journal of neuro-oncology

authors： Hamisch C,Ruge M,Kellermann S,Kohl AC,Duval I,Goldbrunner R,Grau SJ

更新日期：2017-06-01 00:00:00